glyNOcalyx™

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Blood Pressure + Endothelial Glycocalyx Support

Next generation cardiovascular formula featuring four clinically studied, plant-based ingredients at clinical strength dosages utilizing our unique SlideTech™ Tablet Coating Technology.

Helps support:  

  • Glycocalyx structural health1 
  • Healthy blood pressure1 
  • Healthy endothelium1
  • Healthy circulation & blood flow1
  • Nitric oxide production1

glyNOcalyx™ includes a unique aged black garlic ingredient, standardized to 0.1% S-allylcysteine (SAC) by HPLC via a proprietary extraction technology that preserves these active compounds. Black garlic extract has been found to help activate eNOS and increase nitric oxide production, and serve as a H2S donor, which can potentiate the effects of nitric oxide.  

Recent research has shown that the polyphenols found in grape seed extracts, most notably proanthocyanidins, can provide many health benefits. In a leading human clinical study, this specific grape seed extract ingredient (standardized to 95% proanthocyanidins) was shown to promote normal blood pressure nearly 2x more effectively than diet and exercise alone.2 

The clinically researched fucoidan in glyNOcalyx™ is a highly characterized, certified organic complex of fucoidan and marine polyphenols sourced from Fucus vesiculosus seaweed. This high-purity, potent antioxidant provides a rich source of polysaccharides that help serve as structural building blocks for the glycocalyx. 

glyNOcalyx™ features a unique melon juice concentrate, obtained from a proprietary variety of cantaloupe melon exclusively grown in the south of France that provides a naturally rich source of Superoxide Dismutaste (SOD). This enzymatic antioxidant has been found to help protect the glycocalyx and provide structure support.  

The endothelial glycocalyx is a micro-thin, sugar-rich layer that has a hair-like resemblance and covers the apical side of vascular endothelial cells, projecting into the lumen of blood vessels. It serves as a protective barrier allowing the blood to flow without impacting the inner wall of the blood vessels. The endothelial cell glycocalyx is negatively charged and heavily hydrated, consisting of a variety of glycosaminoglycans chains such as heparan sulfate and chondroitin sulfate as well as lipoprotein lipase, chemokines and other blood borne proteins.  

 

Important functions of the glycocalyx include:  

  • Helps repel erythrocytes and protects endothelial cells from shear stress resulting from blood flow  

  • Limits the adhesion of platelets and leucocytes with the endothelium preventing trans-endothelial migration and chemotaxis  

  • Binds ligands and enzymes, which facilitate cellular and enzymatic modifications   

  • Binds enzymes, such as superoxide dismutase, that scavenge free radicals thereby reducing oxidative stress  

  • Regulates vascular tone by adjusting eNOS activity and nitric oxide production  

 

Daily Benefits of glyNOcalyx  

 

Our powerhouse glyNOcalyx formula takes cardiovascular health support a step further by targeting key factors that impact blood pressure, endothelial glycocalyx, nitric oxide production, and overall cardiovascular health.  

 

Helps support:  

  • Glycocalyx structural health1 

  • Nitric Oxide production1 

  • Healthy Endothelium1  

  • Healthy Blood Pressure1  

  • Healthy Circulation & Blood Flow1  

  • Inflammatory Response1  

  • Reduced Oxidative Stress1 

 

Direction:As a dietary supplement, take one (1) tablet daily or as directed by your healthcare professional.  

 

Precaution: For adult use only. Consult a physician if are pregnant, nursing, taking medications, or have a medical condition. Keep out of reach of children.

Supporting a Healthy Endothelial Glycocalyx 

The glycocalyx is a very delicate structure that can become worn down over time from poor diet, lack of exercise, smoking, genetics, natural aging process, along with other factors.  

Recent research has shown that certain nutrients, antioxidants, and lifestyle can serve as foundational building blocks to help support a healthy glycocalyx. Targeted ways to support the glycocalyx include: 

  • Maintain a well-balanced diet 

  • Supplement with glycosaminoglycans, and sulfated polysaccharides primarily from marine algae 

  • Reduce oxidative stress and support a healthy inflammatory response with appropriate nutrients 

  • Supplement with heparinase inhibitors 

  • Engage in appropriate physical activity 

  • Support healthy blood pressure  

Supporting a Healthy Endothelial Glycocalyx 

The glycocalyx is a very delicate structure that can become worn down over time from poor diet, lack of exercise, smoking, genetics, natural aging process, along with other factors.  

Recent research has shown that certain nutrients, antioxidants, and lifestyle can serve as foundational building blocks to help support a healthy glycocalyx. Targeted ways to support the glycocalyx include: 

  • Maintain a well-balanced diet 

  • Supplement with glycosaminoglycans, and sulfated polysaccharides primarily from marine algae 

  • Reduce oxidative stress and support a healthy inflammatory response with appropriate nutrients 

  • Supplement with heparinase inhibitors 

  • Engage in appropriate physical activity 

  • Support healthy blood pressure  

Supporting a Healthy Endothelial Glycocalyx 

The glycocalyx is a very delicate structure that can become worn down over time from poor diet, lack of exercise, smoking, genetics, natural aging process, along with other factors.  

Recent research has shown that certain nutrients, antioxidants, and lifestyle can serve as foundational building blocks to help support a healthy glycocalyx. Targeted ways to support the glycocalyx include: 

  • Maintain a well-balanced diet 

  • Supplement with glycosaminoglycans, and sulfated polysaccharides primarily from marine algae 

  • Reduce oxidative stress and support a healthy inflammatory response with appropriate nutrients 

  • Supplement with heparinase inhibitors 

  • Engage in appropriate physical activity 

  • Support healthy blood pressure  

SlideTech™ Tablet Technology

glyNOcalyx tablets utilize proprietary SlideTech™ coating technology. Our unique tablets utilize a clean-coating without the use of any artificial colors & dyes and produces a smooth glide and easy-to-swallow experience. These coated tablets are specially formulated to avoid dose-dumping and support gentle absorption without potential digestive issues you may experience with instant-release capsules.  

SlideTech™ Tablet Technology

glyNOcalyx tablets utilize proprietary SlideTech™ coating technology. Our unique tablets utilize a clean-coating without the use of any artificial colors & dyes and produces a smooth glide and easy-to-swallow experience. These coated tablets are specially formulated to avoid dose-dumping and support gentle absorption without potential digestive issues you may experience with instant-release capsules.  

Related Clinical Studies and Published Researched

Optimized Aged Garlic Extract on Blood Pressure Support 

Grape Seed Procyanidins in Pre- and Mild Hypertension

Heparan Sulfate Mimetic Fucoidan and Endothelial Glycocalyx

The endothelial glycocalyx: composition, functions, and visualization

Optimized Aged Garlic Extract on Blood Pressure Support 

Grape Seed Procyanidins in Pre- and Mild Hypertension

Heparan Sulfate Mimetic Fucoidan and Endothelial Glycocalyx

The endothelial glycocalyx: composition, functions, and visualization

Frequently Asked Questions

What’s the best way to take this product?

As a dietary supplement, take one (1) tablet daily or as directed by your healthcare professional. 

How many come in a bottle?

There are 30 tablets per bottle, or 30 total servings, or 1-month supply. 

What are the key ingredients?

Black Garlic Extract – 250mg  

Grape Seed Extract – 150mg  

Fucoidan Extract – 100mg  

Melon Juice Concentrate – 10mg

For questions, please call 855-636-4040

 

90 Day Satisfaction Guarantee

HumanN® offers a 90-day money-back guarantee. We want you to be fully satisfied. If you are not satisfied, you may return the item within 90 days from the order date for a full refund of the purchase price, minus the shipping and handling charge. Please note that free shipping offer applies to Continental U.S. only.

Precaution: For adult use only. Consult with a physician if you are pregnant/nursing, taking medications or have a medical condition. Keep out of reach of children. 

1These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.  

2 In a 16-week, double-blind, placebo-controlled study involving 119 men and women, glyNocalyx’ polyphenol compound, taken as part of a lifestyle that includes diet and exercise, was clinically shown to be nearly 2-times as effective at helping to support blood pressure than diet and exercise alone.