Blood Pressure + Endothelial Glycocalyx Support
Next generation cardiovascular formula featuring four clinically studied, plant-based ingredients at clinical strength dosages utilizing our unique SlideTech™ Tablet Coating Technology.
Helps support:
glyNOcalyx™ includes a unique aged black garlic ingredient, standardized to ≥0.1% S-allylcysteine (SAC) by HPLC via a proprietary extraction technology that preserves these active compounds. Black garlic extract has been found to help activate eNOS and increase nitric oxide production, and serve as a H2S donor, which can potentiate the effects of nitric oxide.
Recent research has shown that the polyphenols found in grape seed extracts, most notably proanthocyanidins, can provide many health benefits. In a leading human clinical study, this specific grape seed extract ingredient (standardized to 95% proanthocyanidins) was shown to promote normal blood pressure nearly 2x more effectively than diet and exercise alone.2
The clinically researched fucoidan in glyNOcalyx™ is a highly characterized, certified organic complex of fucoidan and marine polyphenols sourced from Fucus vesiculosus seaweed. This high-purity, potent antioxidant provides a rich source of polysaccharides that help serve as structural building blocks for the glycocalyx.
glyNOcalyx™ features a unique melon juice concentrate, obtained from a proprietary variety of cantaloupe melon exclusively grown in the south of France that provides a naturally rich source of Superoxide Dismutaste (SOD). This enzymatic antioxidant has been found to help protect the glycocalyx and provide structure support.
The endothelial glycocalyx is a micro-thin, sugar-rich layer that has a hair-like resemblance and covers the apical side of vascular endothelial cells, projecting into the lumen of blood vessels. It serves as a protective barrier allowing the blood to flow without impacting the inner wall of the blood vessels. The endothelial cell glycocalyx is negatively charged and heavily hydrated, consisting of a variety of glycosaminoglycans chains such as heparan sulfate and chondroitin sulfate as well as lipoprotein lipase, chemokines and other blood borne proteins.
Important functions of the glycocalyx include:
Helps repel erythrocytes and protects endothelial cells from shear stress resulting from blood flow
Limits the adhesion of platelets and leucocytes with the endothelium preventing trans-endothelial migration and chemotaxis
Binds ligands and enzymes, which facilitate cellular and enzymatic modifications
Binds enzymes, such as superoxide dismutase, that scavenge free radicals thereby reducing oxidative stress
Regulates vascular tone by adjusting eNOS activity and nitric oxide production
Daily Benefits of glyNOcalyx™
Our powerhouse glyNOcalyx™ formula takes cardiovascular health support a step further by targeting key factors that impact blood pressure, endothelial glycocalyx, nitric oxide production, and overall cardiovascular health.
Helps support:
Glycocalyx structural health1
Nitric Oxide production1
Healthy Endothelium1
Healthy Blood Pressure1
Healthy Circulation & Blood Flow1
Inflammatory Response1
Reduced Oxidative Stress1
Direction: As a dietary supplement, take one (1) tablet daily or as directed by your healthcare professional.
Precaution: For adult use only. Consult a physician if are pregnant, nursing, taking medications, or have a medical condition. Keep out of reach of children.
The glycocalyx is a very delicate structure that can become worn down over time from poor diet, lack of exercise, smoking, genetics, natural aging process, along with other factors.
Recent research has shown that certain nutrients, antioxidants, and lifestyle can serve as foundational building blocks to help support a healthy glycocalyx. Targeted ways to support the glycocalyx include:
Maintain a well-balanced diet
Supplement with glycosaminoglycans, and sulfated polysaccharides primarily from marine algae
Reduce oxidative stress and support a healthy inflammatory response with appropriate nutrients
Supplement with heparinase inhibitors
Engage in appropriate physical activity
Support healthy blood pressure
The glycocalyx is a very delicate structure that can become worn down over time from poor diet, lack of exercise, smoking, genetics, natural aging process, along with other factors.
Recent research has shown that certain nutrients, antioxidants, and lifestyle can serve as foundational building blocks to help support a healthy glycocalyx. Targeted ways to support the glycocalyx include:
Maintain a well-balanced diet
Supplement with glycosaminoglycans, and sulfated polysaccharides primarily from marine algae
Reduce oxidative stress and support a healthy inflammatory response with appropriate nutrients
Supplement with heparinase inhibitors
Engage in appropriate physical activity
Support healthy blood pressure
The glycocalyx is a very delicate structure that can become worn down over time from poor diet, lack of exercise, smoking, genetics, natural aging process, along with other factors.
Recent research has shown that certain nutrients, antioxidants, and lifestyle can serve as foundational building blocks to help support a healthy glycocalyx. Targeted ways to support the glycocalyx include:
Maintain a well-balanced diet
Supplement with glycosaminoglycans, and sulfated polysaccharides primarily from marine algae
Reduce oxidative stress and support a healthy inflammatory response with appropriate nutrients
Supplement with heparinase inhibitors
Engage in appropriate physical activity
Support healthy blood pressure
glyNOcalyx tablets utilize proprietary SlideTech™ coating technology. Our unique tablets utilize a clean-coating without the use of any artificial colors & dyes and produces a smooth glide and easy-to-swallow experience. These coated tablets are specially formulated to avoid dose-dumping and support gentle absorption without potential digestive issues you may experience with instant-release capsules.
glyNOcalyx tablets utilize proprietary SlideTech™ coating technology. Our unique tablets utilize a clean-coating without the use of any artificial colors & dyes and produces a smooth glide and easy-to-swallow experience. These coated tablets are specially formulated to avoid dose-dumping and support gentle absorption without potential digestive issues you may experience with instant-release capsules.
Optimized Aged Garlic Extract on Blood Pressure Support
Grape Seed Procyanidins in Pre- and Mild Hypertension
Heparan Sulfate Mimetic Fucoidan and Endothelial Glycocalyx
The endothelial glycocalyx: composition, functions, and visualization
Optimized Aged Garlic Extract on Blood Pressure Support
Grape Seed Procyanidins in Pre- and Mild Hypertension
Heparan Sulfate Mimetic Fucoidan and Endothelial Glycocalyx
The endothelial glycocalyx: composition, functions, and visualization
As a dietary supplement, take one (1) tablet daily or as directed by your healthcare professional.
There are 30 tablets per bottle, or 30 total servings, or 1-month supply.
Black Garlic Extract – 250mg
Grape Seed Extract – 150mg
Fucoidan Extract – 100mg
Melon Juice Concentrate – 10mg
90 Day Satisfaction Guarantee
HumanN® offers a 90-day money-back guarantee. We want you to be fully satisfied. If you are not satisfied, you may return the item within 90 days from the order date for a full refund of the purchase price, minus the shipping and handling charge. Please note that free shipping offer applies to Continental U.S. only.
Precaution: For adult use only. Consult with a physician if you are pregnant/nursing, taking medications or have a medical condition. Keep out of reach of children.
1These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
2 In a 16-week, double-blind, placebo-controlled study involving 119 men and women, glyNocalyx’ polyphenol compound, taken as part of a lifestyle that includes diet and exercise, was clinically shown to be nearly 2-times as effective at helping to support blood pressure than diet and exercise alone.